Progress in mechanism of tumor-derived exosomes on myeloid-derived suppressor cells
10.3760/cma.j.cn112309-20220427-00138
- VernacularTitle:肿瘤来源的外泌体对髓源抑制细胞的作用机制研究进展
- Author:
Mengyu ZHANG
1
;
Jie SHEN
;
Meiyu PENG
Author Information
1. 潍坊医学院免疫学实验室，潍坊 261053
- Keywords:
Myeloid-derived suppressor cells;
Tumor microenvironment;
Tumor-derived exosomes;
Immunosuppression;
miRNA
- From:
Chinese Journal of Microbiology and Immunology
2022;42(11):912-916
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cells (MDSCs) play an important immunosuppressive role in the tumor microenvironment. Tumor cells can regulate the immunosuppressive function of MDSCs in the tumor microenvironment through exosomes, thereby affecting the development of tumors. Tumor-derived exosomes (TEXs) promote the development of MDSCs and improve their immunosuppressive function in the tumor microenvironment mainly by participating in the processes such as intercellular information exchange and information transmission. Moreover, the miRNAs in TEXs will also be transferred to recipient cells to inhibit the immunosuppressive function of MDSCs by inducing the negative regulation of target genes. This review summarized the progress in the mechanism of TEXs on MDSCs.
