Progress in pathogenic mechanisms of neurotropic viruses crossing blood-brain barrier and invading central nervous system
10.3760/cma.j.cn112309-20220113-00012
- VernacularTitle:嗜神经病毒穿越血脑屏障入侵中枢神经系统的相关致病机制研究进展
- Author:
Yu ZHANG
1
;
Haifeng LIU
;
Xiaoning LIU
;
Yuantao ZHOU
;
Lyuyan TAO
;
Xiaoli HE
;
Yang XIAO
;
Li LI
Author Information
1. 昆明市儿童医院云南省儿科研究所，云南省儿童重大疾病研究重点实验室，云南省儿童健康与疾病临床医学研究中心，昆明 650228
- Keywords:
Neurotropic viruses;
Blood-brain barrier;
Central nervous system;
Pathogenic mechanisms
- From:
Chinese Journal of Microbiology and Immunology
2022;42(11):906-911
- CountryChina
- Language:Chinese
-
Abstract:
Blood-brain barrier is a natural barrier between blood and brain tissue that can protect the brain from invasion by infectious pathogens in blood and maintain the homeostasis of the brain environment. However, neurotropic viruses can escape or disrupt blood-brain barrier and then invade the brain, causing serious complications in the central nervous system such as encephalitis and meningitis, which seriously threaten human life. This paper mainly summarized the research progress in the pathogenic mechanisms of common neurotropic viruses crossing blood-brain barrier and invading the central nervous system.
