Research progress in the role of glucose-regulated protein 78 in mucormycosis
10.3760/cma.j.cn112309-20220418-00121
- VernacularTitle:葡萄糖调节蛋白78在毛霉感染中的研究进展
- Author:
Hang RUAN
1
;
Xiao RAN
;
Qin ZHANG
;
Yiming TAO
;
Shusheng LI
Author Information
1. 华中科技大学同济医学院附属同济医院重症医学科，武汉 430030
- Keywords:
Mucormycosis;
Glucose-regulated protein 78 (GRP78);
Targeted therapy
- From:
Chinese Journal of Microbiology and Immunology
2022;42(11):894-898
- CountryChina
- Language:Chinese
-
Abstract:
Mucormycosis is an infectious disease characterized by rapidly progressive vascular invasiveness, thrombosis and tissue necrosis, which could be potentially responsible for blocking the exudation of leukocytes to infection sites and affecting drug distribution. Glucose-regulated protein 78 (GRP78) is a key protein involved in regulating the invasiveness of Mucorales. Endoplasmic reticulum GRP78 is overexpressed under various stress conditions and transported to the cell membrane to become a cell surface receptor for Mucorales entering into vascular endothelial cells. This article reviewed the mechanisms and pathogenesis of GRP78-mediated host cell invasion and summarized the progress in related targeted drugs, aiming to provide reference for developing multi-target intervention against mucormycosis.
