Progress in Gasdermin B gene and its related diseases

VernacularTitle:Gasdermin B基因及其相关疾病的研究进展
Author: Jingxuan WAN ¹ ; Jingyuan ZHANG ; Mengyuan ZHANG ; Chunxiao LI ; Jiangtao LIN
Author Information

1. 中日友好医院呼吸与危重症医学科，北京　100029
Keywords: Gasdermin B (GSDMB); Pyroptosis; Asthma; Cancer
From: Chinese Journal of Microbiology and Immunology 2022;42(10):831-836
CountryChina
Language:Chinese
Abstract: Human Gasdermin B (GSDMB) gene, as a member of the Gasdermin (GSDM) gene family, may be associated with the development of asthma, tumor and immune system diseases. Recent studies have found that cell pyroptosis can be mediated by GSDMB protein. The N-terminus of GSDMB cleaved by Granzyme A (GZMA), which is secreted by cytotoxic lymphocytes, can directly promote cell pyroptosis. Moreover, GSDMB protein promotes the cleavage of Gasdermin D (GSDMD) by binding to cysteinyl aspartate specific proteinase-4 (caspase-4), thus indirectly promoting cell pyroptosis. This article summarized the progress in the mechanism of GSDMB gene-mediated cell pyroptosis and the related diseases.