Progress in complement receptor and co-inhibitory molecule VSIG4
10.3760/cma.j.cn112309-20211101-00362
- VernacularTitle:补体受体及共抑制分子VSIG4的研究进展
- Author:
Xiaojie CHEN
1
;
Shipeng LI
;
Liying SUN
;
Zhijun ZHU
Author Information
1. 首都医科大学附属北京友谊医院普外科肝脏移植中心，国家消化系统疾病临床医学研究中心，北京 100050
- Keywords:
VSIG4;
Macrophages;
Innate immunity;
Adaptive immunity
- From:
Chinese Journal of Microbiology and Immunology
2022;42(9):749-752
- CountryChina
- Language:Chinese
-
Abstract:
V set and Ig domain containing 4 (VSIG4), a co-inhibitory molecule expressed by macrophages, is a B7 family-related protein. It can serve as the second signal of T cell activation and regulate the function of T cells. It has been found that VSIG4 is essential in maintaining immune tolerance. Moreover, VSIG4 can also act as a complement receptor, playing a role in recognizing pathogens, regulating the complement alternative pathway and inhibiting inflammatory response. This review summarized the expression of VSIG4 and its role in the immune system.
