Progress in regulatory effects of thymic stromal lymphopoietin on immune cells

VernacularTitle:胸腺基质淋巴细胞生成素对免疫细胞的调控作用及其研究进展
Author: Yuxin CHEN ¹ ; Jianli GAO ; Yun XU
Author Information

1. 浙江中医药大学第二临床医学院，杭州　310053
Keywords: Thymic stromal lymphopoietin; Immune cells; Regulatory mechanism
From: Chinese Journal of Microbiology and Immunology 2022;42(9):729-736
CountryChina
Language:Chinese
Abstract: Thymic stromal lymphopoietin (TSLP), as a pleiotropic cell growth factor, not only participants in the processes of human skin fibrosis, epidermal proliferation and angiogenesis, but also plays a critical role in regulating a variety of immune cells in immune-related diseases (such as respiratory diseases and allergic diseases). TSLP regulates various innate immune cells (such as dendritic cells, mast cells, macrophages, eosinophils, basophils, natural killer T cells and innate lymphocytes) and adaptive immune cells (T lymphocytes and B lymphocytes) mainly through JAK/STAT, NF-κB and other signal pathways mediated by TSLP receptor. This paper summarized the progress in the regulatory roles of TSLP in the proliferation, differentiation and function of various immune cells.