Various features of Chlamydia trachomatis aberrant reticulate body under different induction conditions in vitro and the possible mechanisms
10.3760/cma.j.cn112309-20220406-00099
- VernacularTitle:沙眼衣原体异常网状体在体外不同诱导条件下的变化特点及可能机制
- Author:
Mei WANG
1
;
Cong YOU
;
Jiangyi WANG
;
Leran ZHAO
;
Lili SHAO
;
Quanzhong LIU
Author Information
1. 天津市第一中心医院，南开大学医学院皮肤性病科，天津 300192
- Keywords:
Chlamydia trachomatis;
Aberrant reticulate body;
Persistent infection;
Genomics;
Proteomics
- From:
Chinese Journal of Microbiology and Immunology
2022;42(8):659-665
- CountryChina
- Language:Chinese
-
Abstract:
Persistent Chlamydia trachomatis urogenital tract infection may lead to pelvic inflammatory disease, ectopic pregnancy and tubal infertility in women, and urethritis, epididymitis and other complications in men, which is a hotspot and chanllenge in disease control at home and abroad. In recent years, many researches have shown that Chlamydia trachomatis aberrant reticulate body may be one of the major causes of persistent infection. This review summarized the genomic and proteomic characteristics of Chlamydia trachomatis aberrant reticulate body induced under various conditions in vitro, aiming to elucidating its role in antimicrobial resistance. The identification of persistent infection-related factors, providing new diagnostic targets for the detection of subclinically refractory long-term infections, is a prerequisite for finding appropriate methods to diagnose and treat the complications of Chlamydia trachomatis infection and is crucial for identifying new targets in the post-genomic era.
