Signal transduction and biological function of tuft cells
10.3760/cma.j.cn112309-20210929-00321
- VernacularTitle:簇细胞的信号传导机制及生物学作用
- Author:
Jiaxin LIU
1
;
Xin ZHENG
;
Xin XU
Author Information
1. 口腔疾病研究国家重点实验室，国家口腔疾病临床研究中心，四川大学华西口腔医院牙体牙髓病科，成都 610041
- Keywords:
Tuft cell;
Type Ⅱ immune response;
Taste receptor;
Microbiota
- From:
Chinese Journal of Microbiology and Immunology
2022;42(8):647-651
- CountryChina
- Language:Chinese
-
Abstract:
Tuft cells are highly specialized epithelial cells with distinct transcriptional profiles and biological functions. Recent studies have revealed that tuft cells are widely existed in a range of tissues, including digestive system, respiratory system and periodontal tissues, playing essential roles in mediating host-microbial interaction and initiating type Ⅱ immune response. Although tuft cells share many commons regarding their morphological characteristics and expression profiles, emerging evidence indicates that tuft cells possess a certain degree of heterogeneity in different tissues or loci. Of note, tuft cells consistently express a variety of taste receptors and their downstream signal transduction machineries to detect and respond a wide range of chemicals in the microenvironment or bacterial metabolites. This review discussed the molecular basis of taste signal transduction and biological functions of tuft cells in different tissues.
