Progress in cross reactivity of neutralizing monoclonal antibodies against dengue virus
10.3760/cma.j.cn112309-20210918-00307
- VernacularTitle:抗登革病毒中和性单克隆抗体交叉反应特性的研究进展
- Author:
Nan CHEN
1
;
Lihui CHAI
;
He XIAO
Author Information
1. 河南大学抗体药物开发技术国家地方联合工程实验室，开封 475004
- Keywords:
Dengue virus;
Cross reaction;
Neutralizing monoclonal antibody
- From:
Chinese Journal of Microbiology and Immunology
2022;42(6):495-499
- CountryChina
- Language:Chinese
-
Abstract:
Neutralizing monoclonal antibodies against dengue virus cross-react with other flaviviruses due to the sequence homology between them, such as the antibodies targeting envelope protein and non-structural protein 1. Apart from exerting protective effects in infected animals, cross-neutralizing antibodies could also cause antibody-dependent enhancement (ADE) in vivo. This review summarized the progress in cross-reactivity of neutralizing antibodies against dengue virus.
