In vitro inhibitory effects of resveratrol on rabies virus
10.3760/cma.j.cn112309-20211015-00343
- VernacularTitle:白藜芦醇对狂犬病病毒体外抑制作用研究
- Author:
Qian LIU
1
;
Qing HE
;
Xiaoyan TAO
;
Pengcheng YU
;
Shuqing LIU
;
Xuexin LU
;
Lifen YANG
;
Wuyang ZHU
Author Information
1. 中国疾病预防控制中心病毒病预防控制所，卫健委生物安全重点实验室，北京 102206
- Keywords:
CVS-11;
Resveratrol;
Viral inhibition
- From:
Chinese Journal of Microbiology and Immunology
2022;42(6):472-477
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the in vitro inhibitory effects of resveratrol on rabies virus. Methods:The challenge virus standard (CVS)-11 strain of rabies virus and BHK-21 cells were used to establish the infection model. In vitro inhibitory effects of resveratrol on rabies virus were analyzed at different stages of infection by direct immunofluorescence and cell fluorescence focus unit assay. Results:Without affecting cell growth, resveratrol could block the adsorption of virus, interfere with the entry of virus into cells and inhibit virus proliferation in a concentration-dependent manner. The inhibition rate could reach up to about 95%. The results of co-incubation experiment showed that 40 μmol/L resveratrol could directly kill the virus.Conclusions:This study indicated that resveratrol inhibited the activity of rabies virus in a concentration-dependent manner.
