The value of event-related potential P300 for diagnosing cognitive impairment after stroke
10.3760/cma.j.issn.0254-1424.2022.07.008
- VernacularTitle:事件相关电位P300在脑卒中后认知障碍中的诊断价值
- Author:
Jing GUO
1
;
Yu PENG
;
Jiaoting JIN
;
Fangfang HU
;
Jin QIAO
Author Information
1. 西安交通大学第一附属医院康复医学科，西安 710061
- Keywords:
Event-related potentials;
Event-related potential P300;
Cognitive impairment;
Stroke
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2022;44(7):610-614
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the utility of event-related potential P300 in diagnosing post-stroke cognitive impairment.Methods:Forty-nine stroke survivors at high risk of cognitive impairment formed the observation group, while 54 healthy volunteers were the control group. General clinical data and Montreal Cognitive Assessment Scale (MoCA) scores were compiled for all of the subjects, and the two groups′ P300 latencies, amplitudes and mean reaction times (MRTs) were compared. A total MoCA score <26 (corrected for education level) was taken as the diagnostic criterion for cognitive impairment. The receiver operating characteristics (ROC) curve was employed to analyze the diagnostic efficacy of P300 for post-stroke cognitive impairment and determine the diagnostic cutoff.Results:(1) The average MoCA score, P300 latency and P300 MRT of the observation group were all significantly different from the control group′s averages. There was, however, no significant difference between the two groups′ median P300 amplitudes. (2) According to the ROC curve analysis, the diagnostic limit of P300 latency was 376.50ms. With the area under the curve 0.795, sensitivity was 70.8% and specificity was 78.9%. The diagnosis cut-off value of P300 MRT was 423.35ms, with the area under the curve 0.695, giving a sensitivity of 80.0% and a specificity of 52.6%.Conclusions:Event-related potential P300 has useful efficacy in diagnosing post-stroke cognitive impairment.
