Hyperbaric oxygen therapy can augment the effectiveness of cognition training for persons with vascular cognitive impairment
10.3760/cma.j.issn.0254-1424.2022.06.008
- VernacularTitle:高压氧联合认知训练治疗血管性认知障碍的疗效及其对血浆中Klotho蛋白和同型半胱氨酸的影响
- Author:
Panpan ZHANG
1
;
Kai ZHAO
;
Ting LIU
;
Jie SHENG
;
Qu′nan WANG
;
Ling GU
Author Information
1. 安徽医科大学第一附属医院康复医学科，合肥 230022
- Keywords:
Vascular cognitive impairment;
Klotho protein;
Homocysteine;
Hyperbaric oxygen therapy;
Cognition training
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2022;44(6):519-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of combining hyperbaric oxygen (HBO) therapy with cognition training for persons with vascular cognitive impairment (VCI).Methods:Forty-two persons with VCI were randomly divided into a control group of 19 and a research group of 23. In addition to basic treatment, the control group was given hyperbaric oxygen therapy once a day, 5 days per week for 4 weeks, while the research group received cognition training along with the hyperbaric oxygen therapy. Each person′s cognition was assessed using the Simple Mental Status Scale (MMSE) before and after the four-week treatment. Meanwhile, 3ml of venous blood was collected before eating in the morning to test the plasma levels of Klotho protein and homocysteine using enzyme-linked immunosorbent assays.Results:After the treatment the average MMSE score had improved significantly in both group, with the improvement in the research group′s average significantly greater than that in the control group. The average plasma levels of Klotho protein and homocysteine had also improved significantly more in the research group. In the control group, the only significant improvement was in the average homocysteine level.Conclusions:Hyperbaric oxygen therapy can be an effective supplement to cognition training for persons with vascular cognitive impairment.
