Progress in application of insulin analogues during pregnancy
10.3760/cma.j.cn113903-20211106-00928
- VernacularTitle:胰岛素类似物在妊娠期应用的研究进展
- Author:
Yihong HUANG
1
;
Shaole SHI
;
Zilian WANG
Author Information
1. 中山大学附属第一医院产科，广州 510080
- Keywords:
Diabetes, gestational;
Insulin aspart;
Insulin lispro;
Insulin detemir
- From:
Chinese Journal of Perinatal Medicine
2022;25(10):776-780
- CountryChina
- Language:Chinese
-
Abstract:
Insulin analogues can reduce gestational hyperglycemia more safely and effectively because their molecular structure and metabolic characteristics are more consistent with the characteristics of gestational glucose metabolism. However, the safety and effectiveness of some insulin analogues in pregnancy remain unclear. At present, only a few insulin analogues, insulin aspart, insulin lispro and insulin detemir, have been approved for use during pregnancy in China. As for misuse or off-label insulin analogues during pregnancy, clinicians should make adjustments based on published clinical safety data. In this review, the safety and progress in the management of gestational hyperglycemia with rapid- and long-acting insulin analogues and insulin degludec/insulin aspart are reviewed to provide reference for insulin therapy during pregnancy.
