Vegetarian diet and vitamin B 12 level in Chinese pregnant women
10.3760/cma.j.cn113903-20220215-00125
- VernacularTitle:孕妇素食与维生素B 12状况的关联性
- Author:
Shuxia WANG
1
;
Shan JIANG
;
Zhenyu YANG
;
Xuehong PANG
;
Ye BI
;
Jie WANG
;
Yifan DUAN
;
Liyun ZHAO
;
Jianqiang LAI
Author Information
1. 中国疾病预防控制中心营养与健康所(国家卫生健康委员会微量元素营养重点实验室,中国疾病预防控制中心母乳科学研究重点实验室),北京 100050
- Keywords:
Vitamin B 12 deficiency;
Vegetarians;
Pregnant women;
Risk factors
- From:
Chinese Journal of Perinatal Medicine
2022;25(10):745-750
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between vegetarian diets and vitamin B 12 levels in Chinese pregnant women. Methods:A cross-sectional survey was used to explore the relationship between vegetarian diets and vitamin B 12 levels in Chinese pregnant women based on data from the Chinese National Nutrition and Health Surveillance (2015-2017). Maternal serum vitamin B 12 concentration was determined by electrochemiluminescence. Background and diet information of all subjects were collected using general and food frequency questionnaires. General Linear Model was used to analyze the difference in serum vitamin B 12 levels between vegetarian and non-vegetarian pregnant women and multivariate logistic regression for examining the relationship between vegetarian diets and vitamin B 12 deficiency (vitamin B 12<150 pmol/L) in pregnant women. Results:A total of 8 366 pregnant women were included in the analysis, and vegetarians accounted for 1.2% (102/8 366). The median serum vitamin B 12 concentrations were 155.8(93.6-212.4) pmol/L and 187.2(127.4-267.6) pmol/L ( Z=-4.22, P<0.001), and the vitamin B 12 deficiency rates were 48.0% (49/102) and 35.0% (2 896/8 264) in vegetarian and non-vegetarian women, respectively. The vitamin B 12 deficiency rate in vegetarian women was 0.89-fold higher than in non-vegetarians (95% CI: 1.24-2.89). Among the vegetarian and non-vegetarian pregnant women, vitamin B 12 deficiency rates during the first, second, and third trimesters were 34.8%(16/46), 54.3%(19/35), 66.7%(14/21), and 20.4%(521/2 559), 32.6%(941/2 886), 50.9%(1 430/2 807), noting for an increasing trend ( Z=23.54 and 2.57, P=0.010 and P<0.001). Conclusions:Vegetarian pregnant women are at high risk of vitamin B 12 deficiency. Compared with non-vegetarian women, vegetarian pregnant women in China have lower vitamin B 12 levels and a higher risk of vitamin B 12 deficiency. Moreover, the risk of vitamin B 12 deficiency will gradually increase during pregnancy.