Research progress on regulatory network of competitive endogenous RNA in trophoblast biological behavior in preeclampsia
10.3760/cma.j.cn113903-20220301-00201
- VernacularTitle:竞争性内源性RNA调控网络在子痫前期滋养层细胞生物学行为中的研究进展
- Author:
Doudou HE
1
;
Xiaotong SUN
;
Tao QU
;
Xueping YANG
;
Chunyang ZHANG
Author Information
1. 甘肃中医药大学第一临床医学院，兰州 730000
- Keywords:
Pre-eclampsia;
RNA, untranslated;
MicroRNAs;
RNA, circular;
Trophoblasts;
Biomarkers;
Gene regulatory networks
- From:
Chinese Journal of Perinatal Medicine
2022;25(9):709-713
- CountryChina
- Language:Chinese
-
Abstract:
Preeclampsia is a unique complication in the second and third trimesters of pregnancy, but its pathogenesis remains unclear and the early diagnosis and treatment methods are yet to be perfect. Termination of pregnancy at the right time is the only way to prevent its deterioration and avoid adverse pregnancy outcomes. In recent years, with the in-depth research, non-coding RNAs has been found to be involved in many important physiological and pathological processes such as proliferation and apoptosis of trophoblast cells and these non-coding RNAs can regulate each other to form an intricate and competitive endogenous RNA regulatory network. This article will introduce the biological roles of non-coding RNAs in regulating the invasion and proliferation of trophoblast cells in patients with preeclampsia and possible regulatory relationship between non-coding RNAs. Furthermore, the potential clinical value of non-coding RNAs as diagnostic biomarkers for preeclampsia and therapeutic targets are also elaborated.
