Research progress in high mobility group box-1 in hypoxic-ischemic brain damage

VernacularTitle:高迁移率族蛋白B1在缺氧缺血性脑损伤中的作用的研究进展
Author: Xiaoli FENG ¹ ; Yihui ZHENG ; Zhenlang LIN
Author Information

1. 温州医科大学附属第二医院（育英儿童医院）新生儿科，温州　325027
Keywords: Hypoxia-ischemia brain; HMGB1 protein; Inflammation
From: Chinese Journal of Perinatal Medicine 2022;25(8):626-630
CountryChina
Language:Chinese
Abstract: Inflammation plays an important part in neonatal hypoxic-ischemic brain damage (HIBD). High mobility group box-1 protein (HMGB1), a neuroinflammatory trigger, has a dual effect on HIBD: in the acute stage, it amplifies the ischemic tissue injury; in the later stage, it is involved in the neurovascular repair and reconstruction. The significance of HMGB1 in the pathogenesis of HIBD is still not fully understood. This review summarizes the role of HMGB1 in HIBD, including its effects on neurons, glial cells and blood-brain barrier, and the underlying mechanisms as well as the progress in research on HMGB1 in immature brain, hoping to provide new ideas for neuroprotection in HIBD.