Levosulpiride-induced Parkinsonim.
- Author:
Joong Seok KIM
1
;
Seok Beum KO
;
Si Ryung HAN
;
Yeong In KIM
;
Kwang Soo LEE
Author Information
1. Department of Neurology, College of Medicine, The Catholic University of Korea, Korea. ks1007@cmc.cuk.ac.kr
- Publication Type:Case Report
- Keywords:
Levosulpiride;
Drug-induced parkinsonism;
[I-123] IPT SPECT
- MeSH:
Dopamine;
Dopamine Plasma Membrane Transport Proteins;
Dopaminergic Neurons;
Humans;
Kidney Failure, Chronic;
Parkinsonian Disorders;
Tomography, Emission-Computed, Single-Photon
- From:Journal of the Korean Neurological Association
2003;21(4):418-421
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The present report discusses four cases of chronic renal failure, which developed symptoms of parkinsonism in response to levosulpiride. The temporal relationship between levosulpiride discontinuation and the disappearance of parkinsonism suggests a causal link. In addition, decreased striatal dopamine transporter bindings assessed by [I-123] IPT SPECT were observed in two patients suggesting that a dopamine blocking agent causes the dysfunction of nigrostriatal dopaminergic neurons and that such injury may be involved in the pathogenesis of drug-induced parkinsonism.
