Research progress of anti-seizure medication combination therapy
10.3760/cma.j.cn113694-20220409-00284
- VernacularTitle:抗癫痫发作药物联合治疗的研究进展
- Author:
Cui ZHU
1
;
Tingtao LIU
;
Xuewu LIU
Author Information
1. 山东大学齐鲁医院神经内科，济南 250022
- Keywords:
Epilepsy;
Antiepileptic drugs;
Refractory epilepsy
- From:
Chinese Journal of Neurology
2022;55(12):1442-1446
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is one of the most common and disabling chronic neurological diseases. About 70% of patients with epilepsy can be fully controlled by available anti-seizure medications, while the remaining 20%-30% are drug-resistant. Drug-resistant epilepsy is also known as refractory epilepsy, and refractory epilepsy usually requires a combination of anti-seizure medications. A reasonable combination of anti-seizure medications can reduce the frequency or even the freedom of seizures. To this end, this article summarized the general principles of anti-seizure medications combination therapy, tolerance and drug interaction, combination and synergism in human studies, and the application of non-ionic anti-seizure medications in combination therapy of refractory epilepsy by reviewing the literature, to improve clinicians′ understanding of combination therapy with anti-seizure medications for refractory epilepsy.
