Glymphatic system in Parkinson′s disease
10.3760/cma.j.cn113694-20220331-00257
- VernacularTitle:胶质淋巴系统在帕金森病中的研究进展
- Author:
Tao WANG
1
;
Xiufang LU
;
Li WANG
Author Information
1. 山西医科大学第二医院神经内科 山西医科大学第二临床医学院，太原 030001
- Keywords:
Parkinson disease;
Aquaporin 4;
alpha-Synuclein;
Amyloid;
tau Proteins;
Glymphatic system;
Perivascular space
- From:
Chinese Journal of Neurology
2022;55(12):1434-1441
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease is a degenerative disease of the central nervous system with abnormal protein deposition in the brain as the main pathological changes. The onset of Parkinson′s disease is related to abnormal deposition protein removal disorders, and the relevant mechanisms are still unclear. The glymphatic system is a metabolic waste and abnormal protein deposition removal system in the brain. In recent years, studies have shown that the changes of aquaporin 4, perivascular space and dural lymphatic vessels in Parkinson′s disease are closely related to the level of relevant pathological proteins in cerebrospinal fluid, leading to the occurrence and development of Parkinson′s disease. The researches on structure and biomarkers of the glymphatic system in Parkinson′s disease in recent years are reviewed in this article.
