Systemic lupus erythematosus combined with Aspergillus fumigatus brain abscess in 2 cases
10.3760/cma.j.cn113694-20220324-00232
- VernacularTitle:系统性红斑狼疮合并烟曲霉菌脑脓肿2例
- Author:
Shijie JIN
1
;
Xiaopeng GUO
;
Hao XING
;
Wenbin MA
;
Yu WANG
Author Information
1. 中国医学科学院北京协和医院神经外科，北京100730
- Keywords:
Lupus erythematosus, systemic;
Aspergillus fumigatus;
Brain abscess;
Central nervous system fungal infection;
Neuropsychiatric lupus
- From:
Chinese Journal of Neurology
2022;55(12):1413-1418
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus (SLE) complicated with Aspergillus fumigatus brain abscess is rare and needs to be differentiated from bacterial brain abscess and neuropsychiatric lupus. This article reports 2 cases of surgically diagnosed SLE combined with Aspergillus fumigatus brain abscess. The first patient was a 34-year-old woman. Six months after the diagnosis of SLE, she developed convulsions and unconsciousness. She was diagnosed as neuropsychiatric lupus at the first hospitalization because of negative imaging. After discharge, repeated head magnetic resonance imaging revealed abscess-like signals. The second patient, a 20-year-old male, developed high fever, convulsions, and unconsciousness 3 years after the diagnosis of SLE, and head imaging showed an abscess-like signal. The etiology of the cerebrospinal fluid of the 2 patients was both negative, and the Aspergillus fumigatus brain abscess was diagnosed by pathology through abscess resection or drainage. After treatment with voriconazole, the symptoms were relieved and the lesions were subsided.
