Anti-amphiphysin-associated paraneoplastic brainstem encephalitis with esophageal neuroendocrine carcinoma: a case report
10.3760/cma.j.cn113694-20220222-00128
- VernacularTitle:抗两性蛋白抗体相关副肿瘤性脑干脑炎伴食管神经内分泌癌1例
- Author:
Yanying WANG
1
;
Chenhui MAO
;
Lu YANG
;
Congwei JIA
;
Liangrui ZHOU
;
Wenjia ZHU
;
Hongzhi GUAN
;
Yicheng ZHU
;
Liying CUI
Author Information
1. 中国医学科学院北京协和医学院北京协和医院神经科，北京 100730
- Keywords:
Paraneoplastic syndromes, nervous system;
Amphiphysin;
Neuroendocrine carcinoma;
Brainstem encephalitis
- From:
Chinese Journal of Neurology
2022;55(11):1298-1302
- CountryChina
- Language:Chinese
-
Abstract:
Paraneoplastic neurological syndromes (PNS) are heterogeneous disorders caused by autoimmune responses of cancer, which can affect any part of the nervous system. Anti-amphiphysin antibody is one of the high-risk PNS antibodies, which is usually associated with small cell lung cancer and breast cancer. However, extrapulmonary neuroendocrine carcinoma is rare in patients with anti-amphiphysin antibody. A case of anti-amphiphysin-associated paraneoplastic brainstem encephalitis with esophageal neuroendocrine carcinoma is reported. The tumor was detected by fluorine 18 fluorodeoxyglucose positron emission tomography and pathologically confirmed by gastroscopic biopsy. The patient′s neurological symptoms were partially improved after treatment of intravenous immunoglobulin and glucocorticoids. However, the disease prognosis is closely related to the accompanying tumor.
