A case of febrile infection-related epilepsy syndrome in children successfully treated with tocilizumab and literature review
10.3760/cma.j.cn113694-20220322-00221
- VernacularTitle:托珠单抗成功治疗儿童发热感染相关癫痫综合征1例及文献复习
- Author:
Ying WANG
1
;
Yanli MA
;
Yuan WANG
;
Jun ZHANG
;
Miao LIU
;
Xiaolei LI
;
Chunge LI
;
Weihua ZHANG
Author Information
1. 郑州大学附属儿童医院 河南省儿童医院 郑州儿童医院神经内科，郑州450018
- Keywords:
Fever;
Infection;
Epilepsy;
Interleukin-6;
Child;
Tocilizumab
- From:
Chinese Journal of Neurology
2022;55(11):1277-1285
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To report a case of tocilizumab successfully used in a child with febrile infection-associated epilepsy syndrome (FIRES), and to provide a new idea for the treatment of FIRES in children.Methods:The diagnosis and treatment of 1 case of FIRES admitted in Children′s Hospital Affiliated to Zhengzhou University on February 15, 2021 were described, and the prognosis and follow-up of the child were evaluated. At the same time, the literatures on tocilizumab in the treatment of children′s FIRES were reviewed.Results:A 5-year-old case of FIRES was reported. The child was extremely refractory to immunotherapy and anti-seizure medicines, anesthetics and ketogenic diet. So he was treated with tocilizumab (each time 4 mg/kg) at the 36th day and 43rd day, and epileptic seizures were controlled 10 days after the 2nd doses of tocilizumab. During a follow-up of 10 months, his epileptic seizures were controlled and the cognitive behavior and speech function were well recovered. At present, only 3 cases of FIRES in children have been reported all over the world. All the seizures were well controlled and no obvious adverse reactions were observed.Conclusions:FIRES is a rare refractory epilepsy syndrome, resistant to many kinds of anti-seizure medicines or even anesthetic agents, which is difficult to treat and has poor prognosis. Preliminary trials have shown that tocilizumab is effective and well tolerated in children with FIRES. It may be a potential therapeutic modality for children with FIRES.
