Diagnosis and treatment of tuberculous meningitis
10.3760/cma.j.cn113694-20220812-00608
- VernacularTitle:结核性脑膜炎的诊治
- Author:
Gang ZHAO
1
;
Linfu ZHOU
;
Hongya ZHANG
Author Information
1. 西北大学医学院神经病学系，西安710068
- Keywords:
Tuberculous meningitis;
Cerebrospinal fluid;
Diagnosis;
Treatment
- From:
Chinese Journal of Neurology
2022;55(10):1154-1160
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculous meningitis (TBM) is one of the most serious and lethal diseases in neurology. The early diagnosis and treatment of TBM still faces severe challenges. Acid-fast staining of cerebrospinal fluid and culture of Mycobacteriumtuberculosis are the "gold standard" for the diagnosis of TBM, but lack sensitivity. With the application of metagenomic next-generation sequencing technology, significant advances have been made in the early diagnosis of TBM. The optimal treatment regimen for TBM remains to be further explored and studied. This article intends to provide an overview of the pathogenesis, pathology, clinical manifestations, diagnosis and treatment advancement of TBM, and provide guidance for clinical practice.
