Research progress of acute reperfusion therapies for acute ischemic stroke in extended time window

VernacularTitle:超时间窗急性缺血性脑卒中再灌注治疗的研究进展
Author: Zekun WANG ¹ ; Juehua ZHU ; Qi FANG
Author Information

1. 苏州大学附属第一医院神经内科，苏州215031
Keywords: Stroke; Brain infarction; Neuroimaging; Reperfusion therapies; Extended time window
From: Chinese Journal of Neurology 2022;55(9):1045-1054
CountryChina
Language:Chinese
Abstract: The reperfusion therapies for acute ischemic stroke (AIS) patients in the past have set strict limits on time window. However, with the imaging assessment algorithms for "tissue window" becoming more mature, the time window for reperfusion therapies has been continuously extended. Nowadays the time window of intravenous thrombolysis has been extended to 9 hours after onset of stroke and is expected to be further broadened to 24 hours. At the same time, clinical studies of mechanical thrombectomy for posterior circulation large vessel occlusion (LVO), LVO with large ischemic cores and distal and medium vessel occlusion are all in hot progress. This article summarized diverse imaging assessment algorithms for "tissue window" and the latest advances of clinical research related to different fibrinolytic drugs for intravenous thrombolysis, mechanical thrombectomy for various vascular occlusion and bridging therapy of AIS in the extended time window. The objective of this review was to provide some references for the clinical diagnosis and therapy of stroke beyond time window.