Coexisting anti-N-methyl-D-aspartate receptor and anti-glutamic decarboxylase antibody- associated encephalitis after herpes simplex virus encephalitis: a case report
10.3760/cma.j.cn113694-20220217-00114
- VernacularTitle:成人单纯疱疹病毒性脑炎后抗N-甲基-D-天冬氨酸受体抗体合并抗谷氨酸脱羧酶抗体双阳性脑炎1例
- Author:
Lishu ZHOU
1
;
Zhijian LIN
;
Juanjuan CHEN
;
Jun WU
;
Lili LIU
;
Weiwei YU
;
Yuzhu GUO
Author Information
1. 安徽医科大学北京大学深圳医院临床学院 北京大学深圳医院神经内科，深圳518036
- Keywords:
Encephalitis, herpes simplex;
Autoimmune diseases of the nervous system;
Autoantibodies;
Receptors, N-methyl-D-aspartate;
Glutamate decarboxylase
- From:
Chinese Journal of Neurology
2022;55(9):1013-1018
- CountryChina
- Language:Chinese
-
Abstract:
Herpes simplex virus encephalitis (HSE) is a common form of viral encephalitis, often with a single-phase course. A case of HSE with abnormal mental behavior as the main manifestation, admitted in Peking University Shenzhen Hospital in Octorber 2020, which improved after sufficient antiviral treatment was reported. After 2 months, abnormal mental behavior with memory deterioration recurred. It was considered as anti-N-methyl-D-aspartate receptor antibody combined with anti-glutamic decarboxylase antibody double-positive encephalitis, and improved after rituximab treatment. At present, there is no clinical report of such double antibody positive autoimmune encephalitis secondary to HSE. The purpose of this case report is to raise clinician awareness of post-HSE autoimmune encephalitis.
