Research progress of the orexinergic system in migraine attack generation

VernacularTitle:食欲素系统参与偏头痛发生的研究进展
Author: Shouyi WU ¹ ; Lei WANG ; Chenlu ZHU ; Yonggang WANG
Author Information

1. 兰州大学第二医院神经内科，兰州730030
Keywords: Hypothalamus; Migraine; Orexin
From: Chinese Journal of Neurology 2022;55(8):921-924
CountryChina
Language:Chinese
Abstract: Migraine is a complex disorder of brain function. The hypothalamus has been identified to play a crucial role in attack generation and secretes various neuropeptides. The orexinergic system plays a role in energy metabolism, arousal, sleep, stress and pain modulation. These disorders are closely related to clinical symptoms of migraine. Therefore, the study of the mechanism of hypothalamic orexinergic system in migraine may provide a new perspective for treatment. This article discusses the relationship between hypothalamic orexin system and migraine premonitory symptoms, and briefly summarizes the possible role and mechanism of hypothalamic orexin system in migraine.