Clinical characteristics of retroperitoneal fibrosis:an analysis of 28 cases
10.3760/cma.j.cn114798-20211214-00914
- VernacularTitle:腹膜后纤维化28例临床分析
- Author:
Xingxing ZHAO
1
;
Dan MA
;
Yajing WANG
;
Liyun ZHANG
Author Information
1. 山西中医药大学基础医学院，晋中 030619
- Keywords:
Retroperitoneal fibrosis;
Immunoglobulin G4-related diseases;
Clinical features;
Diagnosis
- From:
Chinese Journal of General Practitioners
2022;21(7):682-685
- CountryChina
- Language:Chinese
-
Abstract:
Clinical data of 28 patients diagnosed with retroperitoneal fibrosis (RPF) in Shanxi Bethune Hospital from September 2014 to September 2020 were retrospectively analyzed. There were 16 males and 12 female with a mean onset age of (56±11) years. The clinical manifestations were lumbago (16/28, 57.14%), abdominal pain (9/28, 32.14%) and back pain (8/28, 28.57%). Inflammatory indexes were elevated in 25 cases (89.29%), and 3 cases had renal insufficiency. Serum IgG4 was elevated in 3 cases (10.71%). Scheel imaging evaluation showed that proportion of type Ⅰ combined with type Ⅲ (abdominal aorta and/or iliac vascular involvement combined with unilateral or bilateral ureteral involvement) was the highest(50.00%, 14/28). followed by. Twenty-seven patients (96.43%) were treated with glucocorticoids and immunosuppressants; 14 patients (50.00%) underwent surgical intervention for ureteral obstruction or hydronephrosis; 6 patients (21.43%) relapsed during hormone withdrawal; 6 patients (21.43%) recovered from the disease and terminated medication; and 13 patients (46.43%) successfully removed the double J tube after lifting ureteral obstruction and hydronephrosis. It is suggested that RPF is more likely to occur in middle-aged and elderly men, with low back pain as the main clinical feature, and ureteral involvement as the main imaging feature. Glucocorticoid combined with immunosuppressive therapy is the conventional treatment. Surgical intervention can relieve acute obstruction and effectively improve the prognosis of patients.
