Correlation between high sensitivity C reactive protein and contrast-induced nephropathy after interventional therapy: a Meta analysis
10.3760/cma.j.cn114798-20220228-00143
- VernacularTitle:高敏C反应蛋白与介入诊疗术后对比剂肾病相关性的Meta分析
- Author:
Shujun LI
1
;
Min CHEN
;
Yuedong SUN
;
Xiangyu TIAN
;
Zilong WANG
;
Xinling ZHOU
;
Xia ZHANG
;
Fazhan ZHOU
Author Information
1. 山东第一医科大学（山东省医学科学院），济南 250117
- Keywords:
High sensitivity C-reactive protein;
Coronary angiography;
Percutaneous coronary intervention;
Contrast-induced nephropathy;
Meta analysis
- From:
Chinese Journal of General Practitioners
2022;21(6):547-553
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the correlation of high sensitivity C-reactive protein (hs-CRP) with contrast-induced nephropathy (CIN) in patients following coronary angiography (CAG) or percutaneous coronary intervention (PCI).Methods:PubMed, web of science, CBM, CNKI and Wanfang Data were searched for studies on hs-CRP levels in patients undergoing CAG or PCI patients from the incipience of the database to March 7, 2021. Meta-analysis was performed by RevMan 5.3 and Stata 12.0 software.Results:Fourteen related studies were included involving 11 885 patients undergoing CAG or PCI (1 034 cases with CIN and 10 851 cases without CIN). The results of meta-analysis showed that the level of hs-CRP in CIN group was significantly higher than that in non-CIN group (WMD=3.77,95 %CI:2.80—4.74, P<0.001, I2=93%), patients with higher levels of hs-CRP before CAG or PCI were more likely to develop CIN. Sensitivity analysis shows that the results of this study had good stability. The results of subgroup analysis show that the differences in sample size, study population, geographical location and the definition of CIN were statistically significant. Conclusion:Available evidence shows that high hs-CRP level is a risk factor for CIN in patients undergoing CAG or PCI, large sample trials are still needed to support this conclusion.
