A systematic review of enteral nutrition versus parenteral nutrition on patient outcomes after liver transplantation
10.3760/cma.j.cn421203-20220420-00080
- VernacularTitle:肠内营养和肠外营养支持对肝移植术后受者治疗效果的荟萃分析
- Author:
Hanjing ZHU
1
;
Mingzhu HUANG
;
Chen PAN
;
Pengfei YANG
;
Yan YANG
Author Information
1. 上海交通大学医学院附属仁济医院护理部，上海 200127
- Keywords:
Liver transplantation;
Enteral nutrition;
Parenteral nutrition;
Meta-analysis
- From:
Chinese Journal of Organ Transplantation
2022;43(7):418-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the therapeutic efficacy of enteral nutrition(EN)versus parenteral nutrition(PN)in patients after liver transplantation(LT).Methods:The databases of Cochrane Library, MEDLINE, EmBase, EBSCO, Sinomed, CBM, CNKI and Wanfang Data were systematically searched up to August 2021 for collecting randomized controlled trials(RCT)of comparing EN and PN in patients after LT.In strict accordance with the inclusion and exclusion criteria, two independent researchers carried out literature screening, data extracting and literature methodological quality evaluations.Then RevMan5.3 software was utilized for quantitative synthesis and statistical processing.Results:A total of 13 RCTs involving 571 grade B patients were included.Meta-analysis indicated that, as compared with PN, serum albumin of EN spiked[WMD=2.5(1.33, 3.68), WMD>0, P<0.000 1], prealbumin rose[WMD=59.78(32.22, 87.35), WMD>0, P<0.000 1], total bilirubin dropped[WMD=-27.81(-41.88, -13.74), WMD<0, P=0.000 1]and infection incidence was significantly lower[ OR=0.25(0.16, 0.39), OR<1, P<0.000 01]. Conclusions:After LT, as compared with PN, EN can boost the nutritional level, promote the recovery of liver function and lower the incidence of postoperative infections.It offers some clinical values.
