Impact of graft/recipient weight ratio on the prognosis of infants with whole liver transplantation
10.3760/cma.j.cn421203-20211227-00322
- VernacularTitle:移植物受者体重比率对婴儿全肝移植预后的影响
- Author:
Shengqiao ZHAO
1
;
Chong DONG
;
Chao SUN
;
Kai WANG
;
Wei ZHANG
;
Chao HAN
;
Hong QIN
;
Fubo ZHANG
;
Weiping ZHENG
;
Zhixin ZHANG
;
Chuyuan SI
;
Wei GAO
Author Information
1. 天津医科大学一中心临床学院，天津 300190
- Keywords:
Liver transplantation;
Graft recipient weight ratio;
Hepatic artery thrombosis;
Small for size syndrome
- From:
Chinese Journal of Organ Transplantation
2022;43(6):352-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the impact of graft recipient weight ratio(GRWR)on pediatric whole liver transplantation in infants aged under 1 year.Methods:From January 2014 to December 2019, clinical data were retrospectively reviewed for 140 children aged under 1 year with whole liver transplantation.They were divided into 3 groups of low GRWR(GRWR<2.5%, 48 cases), middle GRWR(2.5%≤GRWR<5%, 73 cases)and high GRWR(GRWR≥5%, 19 cases). Basic profiles, major postoperative complications and survival rate of graft/recipient were compared.Results:There were 62 males and 78 females with an average age of (7.34±1.81)months and an average weight of(6.81±1.09)kg.The median GRWR was 3.27%(1.33%~8.12%). The higher level of GRWR, the greater age, weight and graft weight of donor in three groups and there was statistical difference ( P<0.05); operative duration, postoperative ICU stay and hospital stay were longer in low GRWR group than those in middle GRWR group and there was statistical difference( P<0.05); The incidence of postoperative hepatic artery thrombosis was higher in low GRWR group than that in middle GRWR group(31.3%vs 8.2%)and there was statistical difference( P<0.05); 4 cases of small-for-size syndrome occurred in low GRWR group, it was significantly different from the other two groups and there was statistical difference( P<0.05); the median follow-up period was(50.7±23.4)months.The survival rates of grafts at 3-month and 1/5-year were 89.6%, 91.8%, 100%; 87.5%, 87.7%, 100%; 87.5%, 87.7%, 100%and there was no inter-group difference( P>0.05). The survival rates of recipients at 3 months, 1 year and 5 years post-operation were 93.8%, 91.8%, 100%; 91.7%, 87.7%, 100%; 91.7%, 87.7%, 100%and there was no inter-group difference( P>0.05). Conclusions:Different from pediatric living donor transplantation, GRWR≥5%does not affect the survival rate of recipient/graft during whole liver transplantation.And GRWR<2.5%may boost the postoperative incidence of hepatic artery thrombosis and small liver syndrome.
