Association analysis of high level of BK virus viruria and HLA site after kidney transplantation
10.3760/cma.j.cn421203-20220301-00031
- VernacularTitle:肾移植术后高水平BK病毒尿症与HLA位点关联分析
- Author:
Boqing DONG
1
;
Yang LI
;
Yuting SHI
;
Jin ZHENG
;
Xiaoming DING
;
Wujun XUE
Author Information
1. 西安交通大学第一附属医院肾移植科 西安交通大学器官移植研究所，西安 710061
- Keywords:
Kidney transplantation;
Human leukocyte antigen;
BK virus;
Delayed graft function;
Risk factors
- From:
Chinese Journal of Organ Transplantation
2022;43(6):321-327
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the temporal distribution of high level of BK virus(BKV) viruria after kidney transplantation(KT)and the association of high level of viruria with clinical factors and specific human leukocyte antigen(HLA)sites in donors and recipients.Methods:From January 1, 2017 to December 31, 2019, clinical data were retrospectively reviewed for 212 recipients of cadaveric KT.A high level of urinary BKV viruria was defined as urinary BKV-DNA quantification>10 7(copies/ml)after KT while 212 recipients with the same gender composition below the threshold during the same period were selected as low-level controls.Clinical data and HLA sites of two groups were statistically analyzed and risk factors for high level of viruria screened by univariate and multifactorial Logistic regressions. Results:The median time to initial high-level BKV infection in urine after RT was 125.5 days.Based upon univariate Logistic analysis, delayed graft function(DGF)and HLA-A24 of recipient were risk factors for high-level BKV infection in urine while HLA-DQ9 of donor acted as a protective factor.Through multivariate Logistic analysis, DGF( OR=2.18, 95% CI 1.18~4.01, P=0.012)and HLA-A24( OR=1.63, 95% CI 1.06~2.53, P=0.027)of recipient were independent risk factors for high-level BKV infection in urine.And HLA-DQ9 of donors( OR=0.58, 95% CI 0.36~0.91, P=0.019)was an independent protective factor. Conclusions:High level of BKV viruria after RT is associated with donor/recipient-specific HLA sites.Early risk factor stratification and protective factors of recipients can aid in tailoring postoperative immunosuppression and screening program and developing T cell-associated vaccines.
