Hepatectomy combined with radiofrequency ablation on liver cross section for hepatocellular carcinoma with microvascular invasion
10.3760/cma.j.cn113855-20220213-00075
- VernacularTitle:肝切除联合肝断面射频消融治疗伴有微血管侵犯肝细胞癌的临床研究
- Author:
Zhipeng TANG
1
;
Dan ZHANG
;
Jianwei QIN
;
Zheng DANG
;
Shulin XU
;
Yuesheng LI
;
Shumei XU
;
Ganqing MA
;
Ruifang FAN
Author Information
1. 中国人民解放军联勤保障部队第940医院普通外科，兰州 730050
- Keywords:
Carcinoma,hepatocellular;
Hepatectomy;
Microvascular invasion;
Radiofrequency ablation;
Liver cross section
- From:
Chinese Journal of General Surgery
2022;37(11):807-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate radiofrequency ablation-assisted liver resection on early recurrence of hepatocellular carcinoma(HCC) with microvascular invasion (MVI).Methods:A total of 82 HCC patients from Jun 2015 to Jun 2020 were divided into assisted group ( n=41) and control group ( n=41) after local hepatectomy.And by pathology,both groups were further substratified into with or without MVI subgroups. Results:There was no statistically significant difference in the baseline data between two groups,nor there was difference in recurrence-free survival rate between the two groups ( χ 2=0.177, P=0.674). However, by subgroup analysis, the recurrence-free survival rate of ablation assisted group was higher than that of the simple local hepatectomy group among MVI positive patients ( χ 2=5.096, P = 0.024).Multivariate analysis showed that only tumor diameter ( HR=1.32, 95% CI: 1.02-1.72, P=0.036) was an independent risk factor for local recurrence at the incisal margin, while mode of operation ( HR=0.15 ,95% CI: 0.04-0.52 ,P=0.003) and MVI ( HR=8.65 ,95% CI: 2.19-34.19 ,P=0.002) were independent risk factors for intrahepatic distant metastasis. Conclusion:Local hepatectomy assisted by intraoperative radiofrequency ablation on hepatic cross section could effectively reduce the postoperative early recurrence rate for hepatocellular carcinoma patients with MVI.
