Total thyroidectomy versus lobectomy for unilateral sporadic medullary thyroid carcinoma
10.3760/cma.j.cn113855-20211107-00632
- VernacularTitle:单侧散发性甲状腺髓样癌原发灶不同切除范围的预后分析
- Author:
Jinming ZHANG
1
;
Jingzhu ZHAO
;
Dongmei HUANG
;
Pengfei GU
;
Jingtai ZHI
;
Xiangqian ZHENG
Author Information
1. 天津市医科大学肿瘤医院甲状腺颈部肿瘤科 国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室 天津市恶性肿瘤临床医学研究中心，天津 300060
- Keywords:
Thyroid neoplasms;
Carcinoma, medullary;
Prognosis;
Hypocalcemia
- From:
Chinese Journal of General Surgery
2022;37(8):579-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the prognosis of patients with unilateral sporadic medullary thyroid carcinoma treated by different surgical selection, and analyze the independent risk factors affecting the prognosis.Methods:One hundred and twenty-six patients at Tianjin Medical University Cancer Institute and Hospital from Feb 2011 to Oct 2018 were retrospectively divided into group A (total thyroiclectomy) and group B (unilateral lobectomy).Results:There were no significant differences in postoperative recurrence rate ( χ2=0.394, P=0.530), mortality ( χ2=3.175, P=0.146), biochemical cure rate ( χ2=0.613, P=0.434), progression free survival and overall survival ( P=0.278, 0.175) between group A and group B; Tumor diameter ≥4 cm and lateral cervical lymph node metastasis were independent risk factors affecting the overall survival. The incidence of postoperative temporary hypocalcemia ( χ2=5.068, P=0.024) and permanent hypocalcemia ( χ2=6.590, P=0.010) in group A was higher than that in group B. Conclusions:Ipsolateral thyroidectomy can be applied to patients with unilateral sporadic medullary thyroid carcinoma with similar long term prognosis and tower incidence of temporary hypocalcemia and permanent hypocalcemia compared to total thyroidectomy.
