The relevance of EZH2 polymorphism to breast cancer risk in Chinese females: results from a multicenter case-control study
10.3760/cma.j.cn113855-20211206-00700
- VernacularTitle:EZH2基因多态性与中国女性乳腺癌易感性的分析
- Author:
Linfeng ZHAO
1
;
Lixiang YU
;
Chao ZHENG
;
Shuya HUANG
;
Liyuan LIU
;
Yujuan XIANG
;
Fei WANG
;
Fei ZHOU
;
Wenzhong ZHOU
;
Chunmiao YE
;
Liang LI
;
Zhongbing MA
;
Qiang ZHANG
;
Qinye FU
;
Zhigang YU
Author Information
1. 山东大学第二医院乳腺外科，济南 250033
- Keywords:
Breast neoplasms;
Disease susceptibility;
Prognosis;
Polymorphisms
- From:
Chinese Journal of General Surgery
2022;37(7):508-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between single nucleotide polymorphism (SNPs) of Zeste homolog enhancer 2 (EZH2) gene and the risk of breast cancer.Methods:Recruiting 1 039 breast cancer patients and 1 040 controls at 22 referral hospitals nationwide in China, the genotype distribution of 3 SNPs loci of EZH2 genes was observed to detect the correlation between different genotypes and the risk of breast cancer genotypes EZH2 expression in breast cancer tissues and its correlation with patient prognosis were analyzed using breast cancer data from the database.Results:EZH2 rs6464926 CC genotype was compared with TT genotype (TT vs. CC: OR=1.362, 95% CI: 1.063-1.746, P=0.015) and dominant model (TC+TT vs .CC: OR=1.22, 95% CI: 1.004-1.483, P=0.045) .In women with BMI ≥24 kg/m 2, the TC genotype ( P=0.050), TT genotype ( P=0.025) and dominant model (TC+TT, P=0.021) of rs6464926 locus were significantly different from CC genotype in cancer risk. rs6464926 was correlated with EZH2 gene expression ( P=6.89E-47). EZH2 gene is highly expressed in breast cancer tissues, and patients with high expression were associated with shorter OS ( HR=1.27, P=0.013), DMFS ( HR=1.37, P<0.01), and RFS ( HR=1.44, P<0.01). Conclusions:The polymorphism rs6464926 of EZH2 gene is associated with breast cancer susceptibility in Chinese women. rs6464926 might regulate breast cancer risk and prognosis by changing EZH2 expression.
