Primary tumor location affects early recurrence of colorectal liver metastases after hepatectomy
10.3760/cma.j.cn113855-20211114-00655
- VernacularTitle:结直肠癌不同部位的原发灶对肝转移瘤根治切除术后早期复发的影响
- Author:
Jiazi YU
1
;
Mingyuan ZHANG
;
Liangbin JIN
;
Leibin SHEN
;
Mian YANG
;
Tao PENG
;
Suzhan ZHANG
Author Information
1. 宁波大学附属李惠利医院结肠肛肠外科，宁波 315020
- Keywords:
Colorectal neoplasms;
Neoplasm metastasis;
Recurrence;
Risk factor
- From:
Chinese Journal of General Surgery
2022;37(6):434-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of different primary sites of colorectal cancer on early recurrence after radical resection of metastatic tumor clinical risk score (CRS).Methods:The data of colorectal cancer liver metastasis (CRLM )surgically resected between Jan 2015 and Feb 2020 were retrospectively analyzed at Li Huili Hospital and Ningbo University People's Hospital. Risk factors leading to early recurrence after CRLM resection were analyzed by univariate analysis, and the significant results were then subjected to multifactorial analysis by COX regression model. Kaplan-Meire method was used to analyze the effect of primary site on disease-free survival at 1 year after CRLM resection in different CRS subgroups.Results:A total of 209 patients were included in the study, including 143 patients with primary tumors in the left colon and 66 in the right colon. One hundred and three (49.3%) patients with recurrence within 1 year.Univariate analysis showed that primary tumor site, neoadjuvant chemotherapy, and CRS were correlated with recurrence. Multivariate analysis showed that right colon cancer, poor efficacy of neoadjuvant therapy, and high risk of CRS were independent risk factors (all P<0.05). Patients with an overall low CRS risk group and low CRS after treatment, had a higher recurrence rate (all P<0.05) within 1 year when primary tumor located right colon. Conclusion:The location of the primary tumor in the right colon is an independent risk factor for recurrence within 1 year after radical surgery in patients with CRLM.
