Doxycycline-moxifloxacin sequential therapy for Mycoplasma genitalium urethritis/cervicitis: a clinical observation
- VernacularTitle:多西环素-莫西沙星序贯疗法治疗生殖支原体尿道炎/宫颈炎的临床观察
- Author:
Sai LI
1
;
Huazhong XUE
;
Shuwen ZHANG
;
Juan JIANG
;
Shuzhen QI
;
Yuanyuan ZHAO
;
Jinping ZHANG
;
Zhong SHA
;
Wenjing LE
;
Biwei WANG
;
Shixuan ZHAO
;
Xiaofeng ZHU
;
Xiaohong SU
Author Information
- Keywords: Mycoplasma genitalium; Mycoplasma infections; Treatment outcome; Doxycycline-moxifloxacin sequential therapy
- From: Chinese Journal of Dermatology 2022;55(12):1092-1095
- CountryChina
- Language:Chinese
- Abstract: Objective:To investigate outcomes and safety of doxycycline-moxifloxacin sequential regimen in the treatment of Mycoplasma genitalium urethritis/cervicitis. Methods:From June 2019 to December 2020, patients with Mycoplasma genitalium urethritis/cervicitis confirmed by nucleic acid amplification testing were successively recruited at Department of Sexually Transmitted Diseases, Hospital of Dermatology, Chinese Academy of Medical Sciences, and received sequential therapy with oral doxycycline for 7 days followed by oral moxifloxacin for 7 days. Clinical and/or etiological assessment was conducted 2 to 3 weeks after the end of treatment. Fisher′s exact test was used to analyze factors influencing the treatment outcome. Results:Totally, 36 eligible subjects were enrolled, including 30 males and 6 females. Among them, 18 (50%) patients completed post-treatment etiological assessment, which showed that 12 achieved microbiological cure, and treatment failures occurred in 6; another 18 patients achieved clinical cure. The overall response rate to doxycycline-moxifloacin sequential therapy was 83.3% (30/36, 95% confidence interval[ CI]: 70.5%, 96.1%) . The treatment outcome showed no significant association with the patients′ age, gender, marital status, number of sexual partners in the past 1 month, history of sexually transmitted diseases, history of antibiotic use in the past 1 month, or co-infections (all P > 0.05) . Conclusion:The efficacy of doxycycline-moxifloacin sequential regimen is limited in the treatment of Mycoplasma genitalium infections in Nanjing area, and clinicians should be alerted to the possibility of treatment failure in clinical practice.
