Tumor necrosis factor-α inhibitor-induced psoriasis
- VernacularTitle:肿瘤坏死因子α抑制剂诱导的银屑病研究进展
- Author:
Jie SUN
1
;
Rui WANG
;
Chengxin LI
Author Information
- Keywords: Psoriasis; Tumor necrosis factor-alpha; Biological agents; Adverse reactions; Tumor necrosis factor-α inhibitor-induced psoriasis
- From: Chinese Journal of Dermatology 2022;55(9):821-824
- CountryChina
- Language:Chinese
- Abstract: Tumor necrosis factor-α (TNF-α) inhibitors have been widely used and proven to be effective in the treatment of various inflammatory disorders in recent years, but there is a noteworthy and paradoxical adverse drug reaction that cannot be ignored, that is, TNF-α inhibitor-induced psoriasis. Its pathological manifestations could be psoriasiform or spongiotic changes, and its pathogenesis may be related to the imbalance between TNF-α and type Ⅰinterferon, the involvement of interleukin-23/T helper 17 axis, or infection. This review elaborates the epidemiological, histopathological features and possible pathogenesis of TNF-α inhibitor-induced psoriasis, and provides a basis for recognition and treatment of TNF-α inhibitor-induced psoriasis.
