Research progress and thinking in mouse models of vitiligo-like depigmentation
- VernacularTitle:白癜风样小鼠皮肤脱色模型研究进展与思考
- Author:
Zhe JIAN
1
;
Jia ZHANG
Author Information
- Keywords: Vitiligo; Melanocytes; Disease models, animal
- From: Chinese Journal of Dermatology 2022;55(7):622-628
- CountryChina
- Language:Chinese
- Abstract: The etiology and pathogenesis of vitiligo have not yet been clear, and animal models are important tools for vitiligo research. In addition to traditional mouse models of vitiligo, many new models have been gradually established with the deepening of research, such as mouse models expressing epidermal melanocytes and melanocyte-reactive T cells, K14-SCF/h3TA2/HLA-A2 triple-transgenic mouse (Vitesse mice) models, autoimmune-induced mouse models, chemical reagent-induced mouse models, etc. Manifestations of these models are highly similar to human vitiligo, their reproducibility and stability have been improved to different extents, and they have already become good models for exploring the pathogenesis of and therapeutic targets for vitiligo, as well as for evaluating therapeutic efficacy. This review summarizes current research progress and existing problems in mouse models of vitiligo-like depigmentation.
