Immune Stimulating Efficacy of Soluble beta-1,3-glucans.
- Author:
Jung Hyun SHIM
1
;
Won A CHOI
;
Jong Wan KIM
;
Hae Sook LEE
;
Tae Woong BAEK
;
Min Cheol CHO
;
Kyung Ae LEE
;
Byung Chan SANG
;
Do Young YOON
Author Information
- Publication Type:Original Article
- Keywords: Soluble beta-1; 3-glucan; immunophamacological activities; antitumor effect
- MeSH: Animals; Antibody Formation; Cell Line; Cytokines; Interleukin-18; Macrophages; Mice; Mice, Inbred ICR; Molecular Weight; Nitrogen; Spleen; Thymus Gland; Wound Healing
- From:Immune Network 2003;3(2):156-163
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: beta-1,3-glucans are well known to enhance the immune reactions, resulting in antitumor, antibacterial, antiviral, anticoagulatory and wound healing activities. beta-1, 3-glucans have various activities depending on molecular weight, degree of branching, conformation, water-solubility and intermolecular association. However, the beta-1,3-glucan linked backbone structure is essential and beta-D-glucopyranosyl units are required for immuno-potentiating activities. RESULT: In this study, we tested the immunophamacological activities of soluble beta-1,3-glucans and confirmed the following activities: (1) IFN-gamma production in PBMCs in the presence or the absence of PHA, LPS, or IL-18; (2) induction of various cytokines in the spleen and thymus; (3) adjuvant effect on the antibody production; (4) nitrogen oxide synthesis in macrophages; (5) the cytotoxic and antitumor effects on cell lines and ICR mice. CONCLUSION: These results strongly suggested that beta-1,3-glucans possessed various immuno-pharmacological activities
