Efficacy and safety of adalimumab in patients with Crohn′s disease
10.3760/cma.j.cn112138-20211019-00716
- VernacularTitle:阿达木单抗治疗克罗恩病患者的有效性和安全性观察
- Author:
Yaoyao LIU
1
;
Yanfang CHEN
;
Juan LIU
;
Lu CHEN
;
Jingjing JIANG
;
Rui SUN
;
Hong CHEN
Author Information
1. 东南大学医学院，南京 210009
- Keywords:
Crohn disease;
Adalimumab;
Validation studies;
Safety
- From:
Chinese Journal of Internal Medicine
2022;61(9):1031-1036
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the effectiveness and safety of adalimumab in Crohn′s disease (CD) patients.Methods:We retrospectively reviewed the charts of 41 CD patients who received adalimumab in Zhongda Hospital Southeast University from January 2020 to August 2021. General clinical data, laboratory results, endoscopy and radiologic findings were collected, meanwhile, disease activity and safety events were evaluated at baseline and at 12, 24 and 48 weeks of administration. Adalimumab was given subcutaneously once every 2 weeks in doses of 160 mg for the first time, 80 mg for the second time, and 40 mg for each subsequent time.Results:The clinical remission rates at 12, 24, and 48 weeks of treatment were 43.9% (18/41), 60.6% (20/33), 60.9% (14/23), and the clinical response rates were 75.6% (31/41), 69.7% (23/33), and 56.5%( 13/23), respectively. The proportion of endoscopic remission at 12, 24 and 48 weeks were 4/14, 2/6, 1/4 in patients undergoing endoscopy, and 1/14 patients achieved mucosal healing at 24 weeks. Primary nonresponse rate (PNR) was 17.1% (7/41), loss of response (LOR) rate was 14.6% (6/41). The incidence of adverse reactions was 9.8%(4/41).Conclusion:Adalimumab can effectively relieve the clinical symptoms and intestinal disease activities of Crohn′s disease, and deserves to be popularized clinically. Patients with disease course <2 years, first-line biologics, low baseline HBI score, and longer duration of medication may have better results.
