Clinical characteristics of 272 437 patients with different histopathological subtypes of primary esophageal malignant tumors
- VernacularTitle:272 437例原发食管恶性肿瘤患者的组织病理学类型和临床病理特征分析
- Author:
Lidong WANG
1
;
Liuyu LI
;
Xin SONG
;
Xueke ZHAO
;
Fuyou ZHOU
;
Ruihua XU
;
Zhicai LIU
;
Aili LI
;
Jilin LI
;
Xianzeng WANG
;
Liguo ZHANG
;
Fangheng ZHU
;
Xuemin LI
;
Weixing ZHAO
;
Guizhou GUO
;
Wenjun GAO
;
Xiumin LI
;
Lixin WAN
;
Jianwei KU
;
Quanxiao XU
;
Fuguo ZHU
;
Aifang JI
;
Huixiang LI
;
Jingli REN
;
Shengli ZHOU
;
Peinan CHEN
;
Qide BAO
;
Shegan GAO
;
Haijun YANG
;
Jinchang WEI
;
Weimin MAO
;
Zhanqiang HAN
;
Zhiwei CHANG
;
Yingfa ZHOU
;
Xuena HAN
;
Wenli HAN
;
Lingling LEI
;
Zongmin FAN
;
Ran WANG
;
Yuanze YANG
;
Jiajia JI
;
Yao CHEN
;
Zhiqiang LI
;
Jingfeng HU
;
Lin SUN
;
Yajie CHEN
;
Helin BAI
;
Duo YOU
Author Information
- Keywords: Esophageal neoplasms; Neoplasms by histologic type; Clinical pathology; Gender; Age of onset
- From: Chinese Journal of Internal Medicine 2022;61(9):1023-1030
- CountryChina
- Language:Chinese
- Abstract: Objective:To characterize the histopathological subtypes and their clinicopathological parameters of gender and onset age by common, rare and sparse primary esophageal malignant tumors (PEMT).Methods:A total of 272 437 patients with PEMT were enrolled in this study, and all of the patients were received radical surgery. The clinicopathological information of the patients was obtained from the database established by the State Key Laboratory of Esophageal Cancer Prevention & Treatment from September 1973 to December 2020, which included the clinical treatment, pathological diagnosis and follow-up information of esophagus and gastric cardia cancers. All patients were diagnosed and classified by the criteria of esophageal tumor histopathological diagnosis and classification (2019) of the World Health Organization (WHO). The esophageal tumors, which were not included in the WHO classification, were analyzed separately according to the postoperative pathological diagnosis. The χ 2 test was performed by the SPSS 25.0 software on count data, and the test standard α=0.05. Results:A total of 32 histopathological types were identified in the enrolled PEMT patients, of which 10 subtypes were not included in the WHO classification. According to the frequency, PEMT were divided into common (esophageal squamous cell carcinoma, ESCC, accounting for 97.1%), rare (esophageal adenocarcinoma, EAC, accounting for 2.3%) and sparse (mainly esophageal small cell carcinoma, malignant melanoma, etc., accounting for 0.6%). All the common, rare, and sparse types occurred predominantly in male patients, and the gender difference of rare type was most significant (EAC, male∶ female, 2.67∶1), followed with common type (ESCC, male∶ female, 1.78∶1) and sparse type (male∶ female, 1.71∶1). The common type (ESCC) mainly occurred in the middle thoracic segment (65.2%), while the rare type (EAC) mainly occurred in the lower thoracic segment (56.8%). Among the sparse type, malignant melanoma and malignant fibrous histiocytoma were both predominantly located in the lower thoracic segment (51.7%, 66.7%), and the others were mainly in the middle thoracic segment.Conclusion:ESCC is the most common type among the 32 histopathological types of PEMT, followed by EAC as the rare type, and esophageal small cell carcinoma and malignant melanoma as the major sparse type, and all of which are mainly occur in male patients. The common type of ESCC mainly occur in the middle thoracic segment, while the rare type of EAC mainly in the lower thoracic segment. The mainly sparse type of malignant melanoma and malignant fibrous histiocytoma predominately occur in the lower thoracic segment, and the remaining sparse types mainly occur in the middle thoracic segment.
