Interpretation on the international consensus of the pathological diagnosis of unilateral primary aldosteronism
10.3760/cma.j.cn311282-20220623-00400
- VernacularTitle:国际单侧原发性醛固酮增多症病理诊断共识解读
- Author:
Yi YANG
1
;
Shasha ZHU
;
Jiayu LI
;
Ying SONG
;
Shumin YANG
;
Wei CHENG
;
Qifu LI
Author Information
1. 重庆医科大学附属第一医院内分泌科 400016
- Keywords:
Unilateral primary aldosteronism;
Pathological diagnosis;
Consensus;
Aldosterone synthase;
Immunohistochemical staining
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(11):937-942
- CountryChina
- Language:Chinese
-
Abstract:
Unilateral primary aldosteronism (UPA) is a common form of PA that is surgically curable by adrenalectomy of the overactive gland. Pathological evaluation of resected adrenals is crucial in the diagnosis of UPA, and its subsequent treatment and follow-up as well. Histomorphological evaluation is the basis for the pathological diagnosis of UPA, and the wide use of aldosterone synthase immunohistochemical staining in recent years has greatly improved the pathological diagnosis of UPA. However, there is a lack of standardized nomenclature and diagnostic criteria. Therefore, consensus on the histopathologic diagnosis of UPA were developed by an international group of pathologists led by Tracy Ann Williams, and published in J Clin Endocrinol Metab, 2021. This article will elaborates on the key points in the consensus to advance the understanding and overall improve clinical mangement of UPA.
