Study on related factors and effect relationship of hyperuricemia in health check-up participants
10.3760/cma.j.cn311282-20220116-00030
- VernacularTitle:健康体检者高尿酸血症相关影响因素及效应关系探讨
- Author:
Lin ZHUO
1
;
Siting CHEN
;
Yihuan GAO
;
Hang LU
;
Xiuying WANG
;
Lang ZHUO
;
Jingqiu CUI
Author Information
1. 天津医科大学总医院内分泌代谢科 300052
- Keywords:
Hyperuricemia;
Dyslipidemias;
Kidney diseases;
Logistic models;
Hypertension;
Correspondence analysis;
Mediating effect
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(10):880-886
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influencing factors of hyperuricemia(HUA) and explore early intervention of metabolic diseases.Methods:A total of 70 523 participants were selected from the database of check-ups in 2016. Univariate analysis and logistic regression analysis were used to identify related factors of HUA. Correspondence analysis was performed for the aggregation of different levels of uric acid(UA) and related factors. The mediating effect of mean blood pressure(MBP) between abnormal metabolic indicators and abnormal renal function was tested.Results:The age, sex, occupation, body mass index(BMI), systolic blood pressure, diastolic blood pressure, blood urea nitrogen(BUN), creatinine(Cr), estimated glomerular filtration rate(eGFR), fasting plasma glucose(FPG), total cholesterol(TC), triacylglycerol(TG), high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol, plasma viscosity were significantly related to HUA( P<0.001). Logistic regression analysis showed that youth, male, hypertension, TC, TG, and Cr were risk factors for HUA, while HDL-C was a protective factor for HUA( P<0.001). Correspondence analysis showed that during the gradual increase of UA, TC was the first to appear abnormal, followed by hypertension and TG, and the increase of Cr appeared last. Mediating effect showed that in changes of UA, the mediating effects of MBP on TC, TG, and HDL-C were 36.35%, 12.63%, and 9.41%, respectively. In changes of eGFR, the mediating effects of MBP on TC, TG and HDL-C were 30.20%, 27.70%, and 6.13%, respectively. Conclusions:UA is positively correlated with blood pressure, TC, and TG, and inversely with HDL-C. TC and TG have an impact on renal impairment, in which MBP plays a mediating role.
