Gestational hypothyroxinemia and offspring autism

VernacularTitle:妊娠低T 4血症与后代自闭症
Author: Yutong HAN ¹ ; Aihua LIU ; Xun GONG ; Zhongyan SHAN
Author Information

1. 中国医科大学附属第一医院内分泌与代谢病科，内分泌研究所，卫健委（共建）甲状腺疾病诊治重点实验室，沈阳　110001
Keywords: Gestational hypothyroxinemia; Autism; Brain development
From: Chinese Journal of Endocrinology and Metabolism 2022;38(9):834-838
CountryChina
Language:Chinese
Abstract: Hypothyroxinemia is a common subclinical thyroid dysfunction in pregnant women. Epidemiological studies have shown that the offspring of maternal hypothyroxinemia have a significantly increased risk of autism, but mechanisms remain unclear. Studies from clinical and animals suggest that thyroid hormone deficiency may lead to irreversible damage to brain development, which may contribute to autism. This review explores the clinical evidence of gestational hypothyroxinemia and autism in offspring and the underlying mechanisms that promote the development and progression of autism. It also emphasizes the importance of early diagnosis and treatment of thyroid disease in pregnancy for the prevention of neurodevelopmental abnormalities in offspring.