A new type of extreme insulin resistance—type C insulin resistance syndrome and its clinical characteristics

VernacularTitle:一种新的极度胰岛素抵抗——C型胰岛素抵抗综合征的临床特点
Author: Siyu LIANG ¹ ; Shi CHEN ; Ming LI ; Tao YUAN ; Lize SUN ; He LIU ; Ou WANG ; Yuxiu LI
Author Information

1. 中国医学科学院，北京协和医学院，北京协和医院内分泌科，卫生部内分泌重点实验室　100730
Keywords: Hyperglycemia; Insulin resistance; Insulin autoimmune syndrome; Insulin antibodies
From: Chinese Journal of Endocrinology and Metabolism 2022;38(8):674-678
CountryChina
Language:Chinese
Abstract: We report on two cases of type C insulin resistance syndrome(TCIRS) admitted to the Department of Endocrinology, Peking Union Medical College Hospital from January 2000 to December 2020. Both patients presented with persistent hyperglycemia, low immunoreactive insulin, extreme insulin resistance, high insulin autoantibodies, high total insulin, and large insulin antibody pool. TCIRS is marked by extreme insulin resistance with ketoacidosis and respond to medium to high doses glucocorticoids rather than plasmapheresis.