The evolving progress of mitochondrial oxidative stress in the pathological mechanisms of diabetic microvascular complications
10.3760/cma.j.cn311282-20211018-00666
- VernacularTitle:线粒体氧化应激在糖尿病微血管并发症发病机制中的研究进展
- Author:
Xin XIONG
1
;
Hua QU
;
Hongting ZHENG
;
Yi ZHENG
Author Information
1. 陆军军医大学第二附属医院内分泌科，重庆 400037
- Keywords:
Mitochondrial oxidative stress;
Diabetic microvascular complications
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(7):613-617
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes complications are the primary cause of disability and mortality in diabetic patients. As the center of cell energy metabolism, mitochondria dysfunction is closely related to the occurrence and development of various microvascular complications. This review focuses on common complications, including diabetic ulcers, diabetic nephropathy and diabetic retinopathy, and on the research progress of mitochondrial function and oxidative stress involving pathological mechanisms of diabetic microvascular complications. We also conclude and update the theoretical basis for targeting mitochondrial oxidative stress in the treatment of these diseases.
