Advances in immunoporosis
10.3760/cma.j.cn311282-20220302-00124
- VernacularTitle:免疫性骨质疏松及其研究进展
- Author:
Junmin CAI
1
;
Houde ZHOU
Author Information
1. 中南大学湘雅二医院国家代谢性疾病临床医学研究中心，代谢性骨病学湖南省重点实验室，代谢内分泌科，长沙 410011
- Keywords:
Immunoporosis;
Osteoimmunology;
Bone remodeling;
Immune cells;
T cells
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(7):558-566
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a common metabolic bone disease, which is involved in disrupted normal bone remodeling process and bone resorption exceeding bone formation. Osteoblasts and osteoclasts play critical roles in maintaining bone homeostasis. In recent years, more and more studies have found that immune cells are involved in the regulation of osteoblast and osteoclast activity via releasing various chemokines and cytokines, and the concept of immunoporosis has been proposed accordingly. This article summarizes the current state of knowledge on the immune system in the pathophysiology of osteoporosis, so as to study and prevent osteoporosis from the perspective of immunology.
