Association of serum chemerin level with early renal insufficiency in patients with type 2 diabetes
10.3760/cma.j.cn311282-20220326-00184
- VernacularTitle:2型糖尿病患者血清趋化素水平与早期肾功能不全的相关性研究
- Author:
Shuoshuo JIN
1
;
Kuangyang CHEN
;
Jiarong DAI
;
Jie SHI
;
Bin LU
;
Weiwei ZHANG
;
Yehong YANG
;
Jie WEN
;
Renming HU
;
Zhen YANG
;
Xuanchun WANG
Author Information
1. 复旦大学附属华山医院内分泌科，上海 200040
- Keywords:
Chemerin;
Diabetes mellitus, type 2;
Glomerular filtration rate;
Urine albumin creatinine ratio
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(6):509-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the correlation between circulating chemerin and two indicators of renal function, estimated glomerular filtration rate (eGFR) and urine albumin creatinine ratio (UACR), in individuals with type 2 diabetes and to determine whether chemerin is an independent marker of early renal insufficiency.Methods:A total of 742 patients with type 2 diabetes were recruited into the cross-sectional community study. Basic information, anthropometric parameters, and biochemical parameters of these individuals were determined and collected, and serum chemerin level was measured using enzyme-linked immunosorbent assay.Results:Chemerin levels were significantly higher in the eGFR-impaired group compared with eGFR-normal group, and macroalbuminuria group compared to the normal or microalbuminuria groups. Spearman′ rank correlation analysis showed serum chemerin level was correlated with eGFR ( r=-0.25, P<0.001), UACR ( r=0.23, P<0.001) and some other biochemical indicators such as triglyceride. And univariate and multivariate logistic regression analyses revealed circulating chemerin was an independent risk factor for eGFR impairment or proteinuria after adjusting corresponding covariates. Receiver operating characteristic (ROC) curve analysis showed that the area under curve (AUC) of circulating chemerin for predicting early impaired eGFR in type 2 diabetes was 0.747, while the AUC of circulating chemerin for predicting macroalbuminuria in type 2 diabetes was 0.748. Conclusion:Circulating chemerin is associated with eGFR or UACR and may be a potential diagnostic marker for early renal insufficiency in type 2 diabetes.
