Variability in reference for serum metabolomics profiles among healthy Han people in different regions of China
10.3760/cma.j.cn311282-20210826-00553
- VernacularTitle:中国不同地域汉族健康人群血清代谢组学参照谱的差异
- Author:
Ye WANG
1
;
Qianqian LIU
;
Zhi ZHENG
;
Feng LIU
;
Jianwei DU
;
Li PAN
;
Xiaolan REN
;
Hailing WANG
;
Ze CUI
;
Xia PENG
;
Jingbo ZHAO
;
Huijing HE
;
Wei SUN
;
Xiaoyan LIU
;
Guangliang SHAN
Author Information
1. 中国医学科学院基础医学研究所，北京协和医学院基础学院流行病与卫生统计学系，北京 100005
- Keywords:
Metabolomics;
Healthy adults;
Reference;
Geographic regions
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(6):475-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish the reference for serum metabolomics profiles among healthy Han adults in China, and explore the variation on metabolomics profiles by geographic regions, sex, and age.Methods:Cross-sectional data and serum samples were obtained from the China National Health Survey. A total of 1 039 male and 1 032 female healthy adults(≥30 years) were included in this study. Serum metabolomics analyses were conducted with ultra-performance liquid chromatography-mass spectrometry(UPLC-MS). Orthogonal partial least squares discriminant analysis(OPLS-DA) was performed to compare the differences of metabolomics among different region, sex, and age.Results:Significant differences on metabolomics profiles were identified among region, sex, and age. A total of 114 region-related metabolites were spotted, including 53 metabolites that involved in human metabolic pathways, mainly peptides(20 metabolites) and glycerophospholipid metabolism-related(14 metabolites). Fifty-nine metabolites were pinned down to be sex-related, among which cotinine was significant in all 7 provinces. Age-related metabolites were only found in Shaanxi and Hainan, with 22 metabolites were recognized.Conclusion:Serum metabolomics varies by geographic regions, sex, and age. When metabolomics is applied for diagnosis or biomarker screening in various studies, it shall take into consideration of setting tailored references.
