Role of microenvironment in the pathogenesis of benign prostatic hyperplasia

VernacularTitle:微环境与良性前列腺增生发病机制的研究进展
Author: Ze’an LI ¹ ; Junjia XIE ; Junxiu CHEN ; Hai HUANG
Author Information

1. 中山大学孙逸仙纪念医院泌尿外科，广州　510021
Keywords: Benign prostatic hyperplasia; Microenvironment; Pathogenesis
From: Chinese Journal of Urology 2022;43(9):717-720
CountryChina
Language:Chinese
Abstract: Benign prostatic hyperplasia (BPH) is a progressive disease causing male lower urinary tract symptoms. The incidence of BPH increases with age. Studies have revealed that the prostate microenvironment is closely related to occurrence and development of BPH. This article reviews the mechanisms of cell components, such as lymphocytes and fibroblasts, inflammatory mediators, such as interleukins and growth factors, hypoxia and oxidative stress in the microenvironment that promote prostate hyperplasia.